Despite many hypotheses, the reason for decreased sperm fertility during in vitro storage remains unclear. It has been reported that the inclusion of antioxidants in the cryopreservation media improved the quality of semen against LPO. This could be due to a poor resistant of goat spermatozoa to cryopreservation stresses compared to sperm from other domesticated mammals, notably bulls. Thus there is a need to improve the current techniques for processing, cooling, packaging and freezing semen with the use of antioxidants. The AI is a common practice in domestic animals, but the use of frozen semen compromises the fertility of goat spermatozoa based on pregnancy rates from AI. This may reduce the oxidative stress and enhance the viability and fertility of goat spermatozoa. Evidence is accumulating towards the lipid peroxidation LPO which may limit the success in this species.